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Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B)

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PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; Protein Phosphatase 2C,Beta Isoform; Protein Phosphatase 1B(formerly 2C),Magnesium-Dependent,Beta Isoform

Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B)
CCC H327
HGNC 9276
MGI 101841
PubMed 22750291
RGD 3374
UniProt O75688
Wiki PPM1B
PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
The deduced 479-amino acid protein shows high sequence similarity to other mammalian PP2C-beta isoforms but has an extended and unique C-terminal portion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Polyclonal Antibody Customized Service Offer
Assay Kits SEH327Hu ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1B (PPM1B) ELISA Kit Customized Service Offer
  1. "The cloning expression and tissue distribution of human PP2Cbeta."FEBS Lett. 431:121-124(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms."J. Biol. Chem. 275:34744-34749(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The 2p21 deletion syndrome: characterization of the transcription content."Genomics 86:195-211(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation."FEBS Lett. 580:4521-4526(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins."Prostate 68:1510-1516(2008) [PubMed] [Europe PMC] [Abstract]
  10. "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation."Cell. Signal. 21:95-102(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."Cell. Signal. 24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]
  13. "PPM1B negatively regulates antiviral response via dephosphorylating TBK1."Cell. Signal. 24:2197-2204(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structural genomics of protein phosphatases." J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract]