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Primase, DNA Polypeptide 2 (PRIM2)

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PRIM2A; p58; DNA primase large subunit; DNA primase 58 kDa subunit

Primase, DNA Polypeptide 2 (PRIM2)
CCC H315
HGNC 9370
MGI 97758
PubMed 16307020
RGD 631433
UniProt P49643
Wiki PRIM2
DNA replication in human cells is initiated by a complex apparatus containing a DNA polymerase-alpha/primase complex that is well conserved from yeast to human. The DNA polymerase-alpha/primase complex contains 4 subunits: the polymerase-alpha p180 (POLA) and p68 (POLA2) subunits, and the primase p58 (PRIM2A) and p49 (PRIM1) subunits. Primase synthesizes oligoribonucleotides that serve as primers for the initiation of DNA synthesis. It plays a role in both the initiation of DNA replication and the synthesis of Okazaki fragments for lagging strand synthesis.
The deduced 446-amino acid protein shares 89% identity with mouse p58, with 5 regions of homology distributed over the central part of the protein. The N and C termini are less well conserved.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Primase, DNA Polypeptide 2 (PRIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Primase, DNA Polypeptide 2 (PRIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Primase, DNA Polypeptide 2 (PRIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Primase, DNA Polypeptide 2 (PRIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Primase, DNA Polypeptide 2 (PRIM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Primase, DNA Polypeptide 2 (PRIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Primase, DNA Polypeptide 2 (PRIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Primase, DNA Polypeptide 2 (PRIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Primase, DNA Polypeptide 2 (PRIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Primase, DNA Polypeptide 2 (PRIM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Primase, DNA Polypeptide 2 (PRIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Primase, DNA Polypeptide 2 (PRIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Primase, DNA Polypeptide 2 (PRIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Primase, DNA Polypeptide 2 (PRIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Primase, DNA Polypeptide 2 (PRIM2) ELISA Kit Customized Service Offer
  1. "DNA replication in vitro by recombinant DNA-polymerase-alpha-primase."Eur. J. Biochem. 222:781-793(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase."J. Biol. Chem. 282:33444-33451(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]