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Protamine 2 (PRM2)

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CT94.2; Cancer/Testis Antigen Family 94,Member 2; Sperm histone P2; Sperm protamine P2

Protamine 2 (PRM2)
CCC H307
HGNC 9448
MGI 97766
PubMed 24146628
RGD 3409
UniProt P04554
Presumably PRM2 is located on human chromosome 16, close to PRM1: in the mouse the corresponding 2 loci are closely linked, and in the Chinese hamster, probes specific for the 2 protamines hybridize to the same restriction fragments after digestion of hamster genomic DNA with any of 5 different restriction endonucleases (Reeves et al., 1987, 1989). The tight linkage may be of functional significance since PRM1 and PRM2 are among the limited number of genes known to be expressed postmeiotically in haploid cells.
In mouse, only one P2 protamine has been detected, whereas in man, the P2 protamine family is represented by 3 protamines, HP2, HP3 and HP4, whose amino acid sequences are identical except at their amino terminal ends .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH307Hu01 Recombinant Protamine 2 (PRM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPH307Hu02 Recombinant Protamine 2 (PRM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPH307Hu03 Recombinant Protamine 2 (PRM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH307Hu01 Polyclonal Antibody to Protamine 2 (PRM2) WB; IHC; ICC; IP.
MAH307Hu21 Monoclonal Antibody to Protamine 2 (PRM2) WB; IHC; ICC; IP.
Assay Kits SEH307Hu ELISA Kit for Protamine 2 (PRM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH307Mu01 Recombinant Protamine 2 (PRM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH307Mu01 Polyclonal Antibody to Protamine 2 (PRM2) WB; IHC; ICC; IP.
Assay Kits SEH307Mu ELISA Kit for Protamine 2 (PRM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protamine 2 (PRM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protamine 2 (PRM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protamine 2 (PRM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protamine 2 (PRM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protamine 2 (PRM2) ELISA Kit Customized Service Offer
  1. "Sequence of human protamine 2 cDNA."Nucleic Acids Res. 16:7733-7733(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered."Genomics 8:127-133(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a human locus in transition."J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Rapid evolution of male reproductive genes in the descent of man."Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular characterization of nuclear basic protein HPI1, a putative precursor of human sperm protamines HP2 and HP3."Eur. J. Biochem. 191:449-451(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Amino acid sequence of the human intermediate basic protein 2 (HPI2) from sperm nuclei. Structural relationship with protamine P2."Eur. J. Biochem. 214:445-450(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Comparison of the amino acid sequences of human protamines HP2 and HP3 and of intermediate basic nuclear proteins HPS1 and HPS2. Structural evidence that HPS1 and HPS2 are pro-protamines."J. Biol. Chem. 263:11059-11063(1988) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2."Biol. Chem. Hoppe-Seyler 367:515-522(1986) [PubMed] [Europe PMC] [Abstract]
  12. "Human sperm protamines. Amino-acid sequences of two forms of protamine P2."Eur. J. Biochem. 156:5-8(1986) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular structure of human protamine P4 (HP4), a minor basic protein of human sperm nuclei."Eur. J. Biochem. 200:387-392(1991) [PubMed] [Europe PMC] [Abstract]