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Phosphatidylserine Synthase 1 (PTDSS1)

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PSSA; PSS1; Serine-exchange enzyme I

Phosphatidylserine Synthase 1 (PTDSS1)
CCC H286
HGNC 9587
MGI 1276575
PubMed 24241535
RGD 1308949
UniProt P48651
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases , like PTDSS1, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE).
The deduced 473-amino acid protein has transmembrane domains and a putative tyrosine phosphorylation site, and it shares 97.3% identity with Chinese hamster PS synthase. Northern blot analysis detected PTDSS1 expression in all human tissues and cell lines examined, with highest levels in heart, lung, liver, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Synthase 1 (PTDSS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Synthase 1 (PTDSS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Synthase 1 (PTDSS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Synthase 1 (PTDSS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Synthase 1 (PTDSS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Synthase 1 (PTDSS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Synthase 1 (PTDSS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Synthase 1 (PTDSS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Synthase 1 (PTDSS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Synthase 1 (PTDSS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Synthase 1 (PTDSS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Synthase 1 (PTDSS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Synthase 1 (PTDSS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Synthase 1 (PTDSS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Synthase 1 (PTDSS1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Control of phosphatidylserine biosynthesis through phosphatidylserine-mediated inhibition of phosphatidylserine synthase I in Chinese hamster ovary cells."Proc. Natl. Acad. Sci. U.S.A. 95:4199-4203(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Purification and characterization of human phosphatidylserine synthases 1 and 2."Biochem. J. 418:421-429(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome." Nat. Genet. 46:70-76(2014) [PubMed] [Europe PMC] [Abstract]