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Glutaminyl Peptide Cyclotransferase (QPCT)

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GCT; QC; EC; Glutaminyl Cyclase; Glutaminyl-tRNA cyclotransferase

Glutaminyl Peptide Cyclotransferase (QPCT)
CCC H274
HGNC 9753
MGI 1917786
PubMed 23183267
RGD 621086
UniProt Q16769
Wiki QPCT
QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
The deduced 361-amino acid protein has a calculated molecular mass of about 41 kD. It contains an N-terminal signal peptide region, several glycosylation and phosphorylation sites, and 2 cysteine residues conserved between the bovine and human enzymes. QPCT shares 86% overall sequence identity with the bovine homolog.Glutaminyl cyclase expression was upregulated in the cortices of individuals with Alzheimer disease and correlated with the appearance of pE-modified amyloid beta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH274Hu01 Recombinant Glutaminyl Peptide Cyclotransferase (QPCT) Positive Control; Immunogen; SDS-PAGE; WB.
APH274Hu01 Active Glutaminyl Peptide Cyclotransferase (QPCT) Cell culture; Activity Assays.
Antibodies PAH274Hu01 Polyclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) WB; IHC; ICC; IP.
MAH274Hu21 Monoclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) WB; IHC; ICC; IP.
Assay Kits SEH274Hu ELISA Kit for Glutaminyl Peptide Cyclotransferase (QPCT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutaminyl Peptide Cyclotransferase (QPCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutaminyl Peptide Cyclotransferase (QPCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutaminyl Peptide Cyclotransferase (QPCT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutaminyl Peptide Cyclotransferase (QPCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutaminyl Peptide Cyclotransferase (QPCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutaminyl Peptide Cyclotransferase (QPCT) ELISA Kit Customized Service Offer
  1. "Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase."J. Mol. Endocrinol. 13:77-86(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions."FEBS Lett. 563:191-196(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery."J. Mol. Biol. 379:966-980(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation."Proc. Natl. Acad. Sci. U.S.A. 102:13117-13122(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis."Biochem. J. 411:181-190(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center."Biochemistry 50:6280-6288(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding."J. Biol. Chem. 286:12439-12449(2011) [PubMed] [Europe PMC] [Abstract]