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Retinoic Acid Early Transcript 1E (RAET1E)

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LETAL; ULBP4; NKG2DL4; N2DL4; RL-4; NKG2D ligand 4; Lymphocyte effector toxicity activation ligand; RAE-1-like transcript 4

Retinoic Acid Early Transcript 1E (RAET1E)
CCC H271
HGNC 16793
MGI 2675273
PubMed 11827464
UniProt Q8TD07
Wiki RAET1E
Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G differ from the other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences.
The deduced 263-amino acid protein contains alpha-1 and alpha-2 domains, a transmembrane domain, and a short cytoplasmic tail. Real-time RT-PCR detected highest expression in skin, with much lower expression in trachea and trace levels in other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Early Transcript 1E (RAET1E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Early Transcript 1E (RAET1E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Early Transcript 1E (RAET1E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Early Transcript 1E (RAET1E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Early Transcript 1E (RAET1E) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Early Transcript 1E (RAET1E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Early Transcript 1E (RAET1E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Early Transcript 1E (RAET1E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Early Transcript 1E (RAET1E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Early Transcript 1E (RAET1E) ELISA Kit Customized Service Offer
  1. "Letal, a tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells."Cancer Biol. Ther. 2:446-451(2003) [PubMed] [Europe PMC] [Abstract]
  2. "ULBP4 is a novel ligand for human NKG2D."Biochem. Biophys. Res. Commun. 305:129-135(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D."J. Immunol. 173:1078-1084(2004) [PubMed] [Europe PMC] [Abstract]
  4. "RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity."J. Biol. Chem. 282:18922-18928(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3."Genomics 79:114-123(2002) [PubMed] [Europe PMC] [Abstract]