Retinoic Acid Receptor Responder 3 (RARRES3)

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene.

RARRES3 is thought act as a tumor suppressor or growth regulator.Sequence analysis predicted that the 164-amino acid RARRES3 protein shares 52% amino acid identity with the putative class II tumor suppressor protein HREV107. RARRES3 and HREV107 both contain a C-terminal hydrophobic domain and 3 myristoylation sites.