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Ras Guanyl Releasing Protein 1 (RASGRP1)

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CALDAG-GEFI; CALDAG-GEFII; RASGRP; hRasGRP1; Calcium and DAG-regulated guanine nucleotide exchange factor II

Ras Guanyl Releasing Protein 1 (RASGRP1)
CCC H251
HGNC 9878
MGI 1314635
PubMed 23532335
RGD 3539
UniProt O95267
Wiki RASGRP1
RASGRP1 is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Guanyl Releasing Protein 1 (RASGRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Guanyl Releasing Protein 1 (RASGRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Guanyl Releasing Protein 1 (RASGRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Guanyl Releasing Protein 1 (RASGRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Guanyl Releasing Protein 1 (RASGRP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Guanyl Releasing Protein 1 (RASGRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Guanyl Releasing Protein 1 (RASGRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Guanyl Releasing Protein 1 (RASGRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Guanyl Releasing Protein 1 (RASGRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Guanyl Releasing Protein 1 (RASGRP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Guanyl Releasing Protein 1 (RASGRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Guanyl Releasing Protein 1 (RASGRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Guanyl Releasing Protein 1 (RASGRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Guanyl Releasing Protein 1 (RASGRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Guanyl Releasing Protein 1 (RASGRP1) ELISA Kit Customized Service Offer
  1. "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia."Proc. Natl. Acad. Sci. U.S.A. 95:13278-13283(1998) [PubMed] [Europe PMC] [Abstract]
  2. "RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions."Mamm. Genome 10:358-361(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus."J. Immunol. 179:4890-4900(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RasGRP links T-cell receptor signaling to Ras."Blood 95:3199-3203(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."J. Cell Biol. 152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP."FASEB J. 16:595-597(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1."EMBO J. 22:3326-3336(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Exchange factors of the RasGRP family mediate Ras activation in the Golgi."J. Biol. Chem. 278:33465-33473(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1."Nature 424:694-698(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus."Mol. Cell. Biol. 24:3485-3496(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Inverted signaling hierarchy between RAS and RAC in T-lymphocytes."Oncogene 23:5823-5833(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells."Blood 105:3648-3654(2005) [PubMed] [Europe PMC] [Abstract]
  14. "A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells."Mol. Cell. Biol. 25:4426-4441(2005) [PubMed] [Europe PMC] [Abstract]
  15. "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1."Mol. Immunol. 45:510-522(2008) [PubMed] [Europe PMC] [Abstract]
  16. "RasGRP1 is required for human NK cell function."J. Immunol. 183:7931-7938(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1."Elife 2:E00813-E00813(2013) [PubMed] [Europe PMC] [Abstract]