Regulatory Factor X 4 (RFX4)

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Transcription factor RFX4; Testis development protein NYD-SP10

Regulatory Factor X 4 (RFX4)
RFX4 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.One cDNA, clone 24, contained the first 3 exons of the ESR1 gene followed by a unique sequence. RNase protection studies indicated that clone 24 mRNA was present in only 1 of 61 breast cancer biopsy samples tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 4 (RFX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 4 (RFX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 4 (RFX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 4 (RFX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 4 (RFX4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 4 (RFX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 4 (RFX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 4 (RFX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 4 (RFX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 4 (RFX4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 4 (RFX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 4 (RFX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 4 (RFX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 4 (RFX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 4 (RFX4) ELISA Kit Customized Service Offer
  1. "Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4."Development 130:4539-4552(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients."Cancer Sci. 96:801-809(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel substrate for tyrosine kinase in human testes."J. Nanosci. Nanotechnol. 5:1236-1239(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members."J. Biol. Chem. 277:836-842(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]