Regulatory Factor X 5 (RFX5)

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DNA-binding protein RFX5

Regulatory Factor X 5 (RFX5)
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome. At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX. RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 5 (RFX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 5 (RFX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 5 (RFX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 5 (RFX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 5 (RFX5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 5 (RFX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 5 (RFX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 5 (RFX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 5 (RFX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 5 (RFX5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 5 (RFX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 5 (RFX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 5 (RFX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 5 (RFX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 5 (RFX5) ELISA Kit Customized Service Offer
  1. "A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)."Genes Dev. 9:1021-1032(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency."Immunity 10:153-162(1999) [PubMed] [Europe PMC] [Abstract]
  6. ErratumImmunity 10:399-399(1999)
  7. "A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y."Mol. Cell. Biol. 20:3364-3376(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex."J. Mol. Biol. 403:40-51(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock."Sci. Signal. 5:RA39-RA39(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex."Mol. Cell. Biol. 20:4455-4461(2000) [PubMed] [Europe PMC] [Abstract]