Regulatory Factor X Associated Protein (RFXAP)

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RFX DNA-binding complex 36 kDa subunit

Regulatory Factor X Associated Protein (RFXAP)
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. RFXAP, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X Associated Protein (RFXAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X Associated Protein (RFXAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X Associated Protein (RFXAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X Associated Protein (RFXAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X Associated Protein (RFXAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X Associated Protein (RFXAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X Associated Protein (RFXAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X Associated Protein (RFXAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X Associated Protein (RFXAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X Associated Protein (RFXAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X Associated Protein (RFXAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X Associated Protein (RFXAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X Associated Protein (RFXAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X Associated Protein (RFXAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X Associated Protein (RFXAP) ELISA Kit Customized Service Offer
  1. "RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency."EMBO J. 16:1045-1055(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency."Immunity 10:153-162(1999) [PubMed] [Europe PMC] [Abstract]
  6. ErratumImmunity 10:399-399(1999)
  7. "Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex."J. Mol. Biol. 403:40-51(2010) [PubMed] [Europe PMC] [Abstract]