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Replication Protein A4 (RPA4)

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RP-A p30; Replication protein A 30 kDa subunit

Replication Protein A4 (RPA4)
CCC H214
HGNC 30305
PubMed 7760808
UniProt Q13156
Wiki RPA4
Replication protein A (RPA) is single-stranded DNA (ssDNA)-binding complex essential for cell viability and chromosome stability. The canonical RPA complex contains RPA1, RPA2, and RPA3. However, RPA4 can substitute for RPA2 to form an alternative RPA complex.
The deduced 261-amino acid protein has a calculated molecular mass of 28.9 kD. RPA4 shares 47% amino acid identity with RPA2, and both proteins have glycine- and serine-rich N-terminal sequences. Western blot analysis detected RPA4 as a 30-kD protein with strong expression in human placenta and low expression in colon. RPA4 expression was also detected in neuroblastoma, colon carcinoma, and Ewing sarcoma cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Protein A4 (RPA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Protein A4 (RPA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Protein A4 (RPA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Protein A4 (RPA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Protein A4 (RPA4) ELISA Kit Customized Service Offer
  1. "Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex."Mol. Cell. Biol. 15:3119-3128(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "An alternative form of replication protein a prevents viral replication in vitro."J. Biol. Chem. 284:5324-5331(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Functions of alternative replication protein A in initiation and elongation."Biochemistry 49:5919-5928(2010) [PubMed] [Europe PMC] [Abstract]
  6. "An alternative form of replication protein a expressed in normal human tissues supports DNA repair."J. Biol. Chem. 285:4788-4797(2010) [PubMed] [Europe PMC] [Abstract]
  7. "A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression."Nucleic Acids Res. 38:846-858(2010) [PubMed] [Europe PMC] [Abstract]