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Restin (RSN)

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CLIP1; CLIP; CLIP-170; CLIP170; CYLN1; CAP-GLY Domain Containing Linker Protein 1; Reed-Steinberg Cell-Expressed Intermediate Filament-Associated Protein

Restin (RSN)
CCC H207
HGNC 10461
MGI 1928401
PubMed 10049780
RGD 67404
UniProt P30622
Binding of endocytic carrier vesicles to microtubules depends on the microtubule-binding protein CLIP170 in vitro. In vivo, CLIP170 colocalizes with a subset of transferrin receptor-positive endocytic structures and, more extensively, with endosomal tubules induced by brefeldin A.
Pierre et al. (1992) identified a novel motif present in a tandem repeat in the N-terminal domain of CLIP170 that is involved in binding to microtubules. This motif is also found in the Drosophila Glued and yeast BIK1 proteins. These features, together with its very elongated structure, suggested that CLIP170 belongs to a novel class of proteins, designated cytoplasmic linker proteins (CLIPs), that mediate interactions of organelles with microtubules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Restin (RSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Restin (RSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Restin (RSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Restin (RSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Restin (RSN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Restin (RSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Restin (RSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Restin (RSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Restin (RSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Restin (RSN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Restin (RSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Restin (RSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Restin (RSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Restin (RSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Restin (RSN) ELISA Kit Customized Service Offer
  1. "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease."EMBO J. 11:2103-2113(1992) [PubMed] [Europe PMC] [Abstract]
  2. "CLIP-170 links endocytic vesicles to microtubules."Cell 70:887-900(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells."Blood 100:4139-4145(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase."EMBO Rep. 3:988-994(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the 1st and 2nd CAP-Gly domain in human CLIP-170/Restin."Submitted (NOV-2005) to the PDB data bank
  15. "Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1."Mol. Cell 27:976-991(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Structure-function relationship of CAP-Gly domains."Nat. Struct. Mol. Biol. 14:959-967(2007) [PubMed] [Europe PMC] [Abstract]
  17. "CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1."Nat. Struct. Mol. Biol. 14:980-981(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition."Proc. Natl. Acad. Sci. U.S.A. 104:10346-10351(2007) [PubMed] [Europe PMC] [Abstract]
  19. "SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase."J. Cell Biol. 193:1083-1099(2011) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]