Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1)

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RS1; Transporter regulator RS1

Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1)
D-glucose is absorbed in the small intestine and kidney by sodium-coupled transport. SGLT1, SAAT1, and Hu14 are homologous integral membrane proteins that mediate sodium-driven transport of D-glucose. A cDNA, pRS1, encoding a membrane-associated protein that alters sugar transport by SGLT1, was cloned from pig kidney cortex.
Lambotte et al. (1996) cloned the intronless human homolog, termed RS1 by them, encoding a 617-amino acid protein with 74% amino acid identity to pRS1. By fluorescence in situ hybridization, the RS1 gene was localized to chromosome 1p36.1. Coexpression of hRS1 and SGLT1 from human intestine in oocytes showed that hRS1 protein inhibits sodium-D-glucose cotransporter expressed by human SGLT1 by decreasing both the V (max) and the apparent K(m) value of the transporter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Solute Carrier Protein Family 1, Member 1 (RSC1A1) ELISA Kit Customized Service Offer
  1. "The human gene of a protein that modifies Na(+)-D-glucose co-transport."DNA Cell Biol. 15:769-777(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C."J. Membr. Biol. 196:71-81(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus."Am. J. Physiol. 291:F1201-F1212(2006) [PubMed] [Europe PMC] [Abstract]
  6. "RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1."Am. J. Physiol. 291:F1213-F1223(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity."J. Biol. Chem. 282:28501-28513(2007) [PubMed] [Europe PMC] [Abstract]