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Selenocysteine Lyase (SCLY)

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SCL

Selenocysteine Lyase (SCLY)
CCC H189
HGNC 18161
MGI 1355310
PubMed 6461656
RGD 1359514
UniProt Q96I15
Wiki SCLY
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium.
The deduced mouse protein has 432 amino acids. RT-PCR detected Scly expression in mouse brain, heart, lung, stomach, liver, kidney, spleen, and testis. Western blot analysis detected expression in all mouse tissues examined, with the highest expression in liver, kidney, and testis. Mouse Scly localized to the cytosolic fraction in mouse liver and formed homodimers.Scly catalyzed the conversion of L-selenocysteine to L-alanine. Scly activity required pyridoxal 5-prime phosphate, was specific to L-selenocysteine, and showed maximum reactivity at pH 9.0.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenocysteine Lyase (SCLY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenocysteine Lyase (SCLY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenocysteine Lyase (SCLY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenocysteine Lyase (SCLY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenocysteine Lyase (SCLY) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenocysteine Lyase (SCLY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenocysteine Lyase (SCLY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenocysteine Lyase (SCLY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenocysteine Lyase (SCLY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenocysteine Lyase (SCLY) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenocysteine Lyase (SCLY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenocysteine Lyase (SCLY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenocysteine Lyase (SCLY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenocysteine Lyase (SCLY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenocysteine Lyase (SCLY) ELISA Kit Customized Service Offer
  1. "cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis."J. Biol. Chem. 275:6195-6200(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Enhanced expression of selenocysteine lyase in acute glomerulonephritis and its regulation by AP-1."Cell. Mol. Biol. Lett. 11:424-437(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of human selenocysteine lyase."Submitted (JUL-2006) to the PDB data bank