SH3 Domain Binding Glutamic Acid Rich Protein (SH3BGR)

Scartezzini et al. (1997) used direct cDNA selection to identify a gene, symbolized SH3BGR, that maps proximal to HMG14 on 21q22.3 and is differentially expressed in heart and skeletal muscle.

SH3BGR encodes a 239-amino acid protein characterized by the presence of a proline-rich region containing the consensus sequence for an SH3-binding domain and by an acidic carboxy-terminal region containing a glutamic acid-rich domain predicted to assume a coiled-coil structure. The presence of 2 functional domains involved in protein-protein interactions suggested to the authors that SH3BGR may be part of a multimeric complex.