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SH3 Domain Binding Protein 5 (SH3BP5)

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SAB; SH3 domain-binding protein that preferentially associates with BTK

SH3 Domain Binding Protein 5 (SH3BP5)
CCC H175
HGNC 10827
MGI 1344391
PubMed 19161832
RGD 620220
UniProt O60239
Wiki SH3BP5
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase crucial for the maturation of B-lineage cells. BTK deficiency is involved in the pathogenesis of X-linked immunodeficiency.
SH3BP5 encodes a deduced 425-amino acid protein. Northern blot analysis revealed wide expression of a 3.0-kb transcript, with especially prominent expression in testis and ovary. Immunoblot analysis showed that SH3BP5 is expressed as a 70-kD protein. Immunoprecipitation analysis suggested that SH3BP5 interacts with BTK in cells. Mutational and immunoblot analyses showed that amino acids 163 to 193 of SH3BP5 bind most strongly to the SH3 domain of BTK and not with the SH3 domains of a number of other cytoplasmic tyrosine kinases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 5 (SH3BP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 5 (SH3BP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 5 (SH3BP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 5 (SH3BP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 5 (SH3BP5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 5 (SH3BP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 5 (SH3BP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 5 (SH3BP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 5 (SH3BP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 5 (SH3BP5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 5 (SH3BP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 5 (SH3BP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 5 (SH3BP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 5 (SH3BP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 5 (SH3BP5) ELISA Kit Customized Service Offer
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  6. "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."Proc. Natl. Acad. Sci. U.S.A. 96:6341-6346(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."Biochem. J. 367:577-585(2002) [PubMed] [Europe PMC] [Abstract]
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  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]