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SH3 Domain Kinase Binding Protein 1 (SH3KBP1)

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CIN85; GIG10; MIG18; HSB-1; CD2BP3; CD2-binding protein 3; Cbl-interacting protein of 85 kDa; Human Src family kinase-binding protein 1

SH3 Domain Kinase Binding Protein 1 (SH3KBP1)
CCC H173
HGNC 13867
MGI 1889583
PubMed 11474197
RGD 620904
UniProt Q96B97
Wiki SH3KBP1
CBL constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor-mediated apoptotic cell death.Sequence analysis predicted that the 665-amino acid protein, 36% identical to CMS, contains 3 consecutive N-terminal SH3 domains followed by a proline-rich region and a C-terminal alpha-helical coiled-coil domain. Northern blot analysis of tissue and cancer cell lines revealed expression of a ubiquitous 3.2-kb transcript as well as of a 2.4-kb transcript in skeletal muscle, kidney, pancreas, and some cancer cell lines. Immunoblot and immunoprecipitation analyses showed expression of an 85-kD protein, larger than the predicted 73 kD, which interacted with CBL.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Kinase Binding Protein 1 (SH3KBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Kinase Binding Protein 1 (SH3KBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Kinase Binding Protein 1 (SH3KBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Kinase Binding Protein 1 (SH3KBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Kinase Binding Protein 1 (SH3KBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Kinase Binding Protein 1 (SH3KBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Kinase Binding Protein 1 (SH3KBP1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl."Biochem. Biophys. Res. Commun. 268:321-328(2000) [PubMed] [Europe PMC] [Abstract]
  2. "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment but elicit divergent functional activities."Int. Immunol. 15:313-329(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization."Cytogenet. Cell Genet. 93:133-134(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes."Biochem. Biophys. Res. Commun. 278:167-174(2000) [PubMed] [Europe PMC] [Abstract]
  8. "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases."J. Biol. Chem. 277:39666-39672(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors."Nature 416:183-187(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met."Nature 416:187-190(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors."Proc. Natl. Acad. Sci. U.S.A. 99:12191-12196(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Dab2 links CIN85 with clathrin-mediated receptor internalization."FEBS Lett. 554:81-87(2003) [PubMed] [Europe PMC] [Abstract]
  13. "SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion."J. Cell Sci. 116:2845-2855(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85."J. Biol. Chem. 278:22396-22403(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization."Proc. Natl. Acad. Sci. U.S.A. 100:6505-6510(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  17. "CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors."Mol. Biol. Cell 15:3155-3166(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex."Mol. Cell. Biol. 24:8981-8993(2004) [PubMed] [Europe PMC] [Abstract]
  19. "CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway."Biochem. Biophys. Res. Commun. 338:808-814(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation."EMBO Rep. 6:635-641(2005) [PubMed] [Europe PMC] [Abstract]
  21. "CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis."Exp. Cell Res. 304:256-264(2005) [PubMed] [Europe PMC] [Abstract]
  22. "CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function."J. Immunol. 175:4208-4216(2005) [PubMed] [Europe PMC] [Abstract]
  23. "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells."Cell 125:535-548(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  25. "CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin."J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract]
  26. "CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP."J. Biol. Chem. 281:28919-28931(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  28. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  33. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  34. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  35. "Cbl promotes clustering of endocytic adaptor proteins."Nat. Struct. Mol. Biol. 12:972-979(2005) [PubMed] [Europe PMC] [Abstract]