Suppressors Of Cytokine Signaling 7 (SOCS7)

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NAP4; NCKAP4; Nck Ash And Phospholipase C Binding Protein; NCK-Associated Protein 4

Suppressors Of Cytokine Signaling 7 (SOCS7)
SOCS7 recruited NCK into the nucleus. Moreover, depletion of NCK from the cytoplasm triggered dissolution of actin stress fibers and loss of cell polarity.
The longest open reading frame encodes a predicted 485-amino acid protein containing several pro-rich sequences, a putative nuclear localization signal, a pro- and gln-rich region characteristic of nuclear proteins, and an SH2 domain. The third pro-rich region of NAP4 was the only region that bound NCK in the yeast 2-hybrid analysis. Northern blot analysis detected a 4.2-kb NAP4 transcript in fetal brain and fetal lung fibroblasts. An 8.3-kb transcript was also detected in fetal lung fibroblasts. RT-PCR showed NAP4 expression in leukocytes and adult brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 7 (SOCS7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 7 (SOCS7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 7 (SOCS7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 7 (SOCS7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 7 (SOCS7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 7 (SOCS7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 7 (SOCS7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 7 (SOCS7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 7 (SOCS7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 7 (SOCS7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 7 (SOCS7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 7 (SOCS7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 7 (SOCS7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 7 (SOCS7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 7 (SOCS7) ELISA Kit Customized Service Offer
  1. "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs."Biochem. Biophys. Res. Commun. 239:488-492(1997) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines."J. Neuroimmunol. 109:34-39(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin."Exp. Cell Res. 298:239-248(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation."J. Biol. Chem. 280:13817-13823(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans."J. Clin. Invest. 115:2462-2471(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7."Cell 130:837-850(2007) [PubMed] [Europe PMC] [Abstract]