Suppressors Of Cytokine Signaling 6 (SOCS6)

[Edit]

CIS4; SOCS4; SSI4; STAI4; STATI4; Cytokine-inducible SH2 protein 4; Suppressor of cytokine signaling 4

Suppressors Of Cytokine Signaling 6 (SOCS6)
SOCS6 belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. CIS4 has a very long N-terminal region of about 380 amino acids; the N-terminal region of other CIF family members is 40 to 80 amino acids in length. CIS4 expression was found to be high in factor-independent chronic myelogenous leukemia (CML) and human erythroleukemia (HEL) cell lines but low in B cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 6 (SOCS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 6 (SOCS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 6 (SOCS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 6 (SOCS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 6 (SOCS6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 6 (SOCS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 6 (SOCS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 6 (SOCS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 6 (SOCS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 6 (SOCS6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 6 (SOCS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 6 (SOCS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 6 (SOCS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 6 (SOCS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 6 (SOCS6) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of novel CIS family genes."Biochem. Biophys. Res. Commun. 239:439-446(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal transduction via the stem cell factor receptor/c-Kit."Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase."J. Biol. Chem. 286:480-490(2011) [PubMed] [Europe PMC] [Abstract]