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Suppressors Of Cytokine Signaling 2 (SOCS2)

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CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2; Cytokine-inducible SH2 protein 2; STAT-induced STAT inhibitor 2

Suppressors Of Cytokine Signaling 2 (SOCS2)
CCC H154
HGNC 19382
MGI 1201787
PubMed 21646394
RGD 69273
UniProt O14508
Wiki SOCS2
SOCS2encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma).
The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH154Hu01 Recombinant Suppressors Of Cytokine Signaling 2 (SOCS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH154Hu01 Polyclonal Antibody to Suppressors Of Cytokine Signaling 2 (SOCS2) WB; IHC; ICC; IP.
Assay Kits SEH154Hu ELISA Kit for Suppressors Of Cytokine Signaling 2 (SOCS2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressors Of Cytokine Signaling 2 (SOCS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressors Of Cytokine Signaling 2 (SOCS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressors Of Cytokine Signaling 2 (SOCS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressors Of Cytokine Signaling 2 (SOCS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressors Of Cytokine Signaling 2 (SOCS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH154Ra01 Recombinant Suppressors Of Cytokine Signaling 2 (SOCS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH154Ra21 Monoclonal Antibody to Suppressors Of Cytokine Signaling 2 (SOCS2) WB; IHC; ICC; IP.
PAH154Ra01 Polyclonal Antibody to Suppressors Of Cytokine Signaling 2 (SOCS2) WB,IHC
Assay Kits SEH154Ra ELISA Kit for Suppressors Of Cytokine Signaling 2 (SOCS2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."Biochem. Biophys. Res. Commun. 237:79-83(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of novel CIS family genes."Biochem. Biophys. Res. Commun. 239:439-446(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor."J. Biol. Chem. 273:24095-24101(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively."Genomics 61:108-111(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase."Proc. Natl. Acad. Sci. U.S.A. 103:7637-7642(2006) [PubMed] [Europe PMC] [Abstract]