Sperm Acrosome Associated Protein 4 (SPACA4)

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SAMP14; Sperm acrosomal membrane-associated protein 14

Sperm Acrosome Associated Protein 4 (SPACA4)
SPACA4 shares highest homology with the Ly6/uPAR superfamily, especially PLAUR, and it has a C-terminal cysteine-rich domain characteristic of Ly6/uPAR proteins. SPACA4 also contains a signal peptide, a transmembrane domain, 4 potential phosphorylation sites, and a transamidase cleavage site, suggesting that SPACA4 is a glycosylphosphatidylinositol (GPI)-anchored protein. Phospholipase C treatment of sperm released SPACA4 into the supernatant, confirming GPI linkage. Northern and dot blot analysis showed a 1.3-kb SPACA4 transcript expressed exclusively in testis. Immunofluorescence analysis localized SPACA4 to the acrosomal region in sperm samples that were stringently washed and in acrosome-reacted sperm. In unwashed sperm samples, SPACA4 localized over the entire sperm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Acrosome Associated Protein 4 (SPACA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Acrosome Associated Protein 4 (SPACA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Acrosome Associated Protein 4 (SPACA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Acrosome Associated Protein 4 (SPACA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Acrosome Associated Protein 4 (SPACA4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Acrosome Associated Protein 4 (SPACA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Acrosome Associated Protein 4 (SPACA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Acrosome Associated Protein 4 (SPACA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Acrosome Associated Protein 4 (SPACA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Acrosome Associated Protein 4 (SPACA4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Acrosome Associated Protein 4 (SPACA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Acrosome Associated Protein 4 (SPACA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Acrosome Associated Protein 4 (SPACA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Acrosome Associated Protein 4 (SPACA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Acrosome Associated Protein 4 (SPACA4) ELISA Kit Customized Service Offer
  1. "SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction."J. Biol. Chem. 278:30506-30515(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]