≡

Single Stranded DNA Binding Protein 1 (SSBP1)

[Edit]

SOSSB1; MtSSB; PWP1-interacting protein 17

Single Stranded DNA Binding Protein 1 (SSBP1)
CCC H126
HGNC 11317
MGI 1920040
PubMed 23178594
RGD 3760
UniProt Q04837
Wiki SSBP1
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis. It is also a subunit of a single-stranded DNA binding complex involved in the maintenance of genome stability.Coimmunoprecipitation analysis confirmed that SOSS complexes formed in HeLa cells independent of DNA damage. SOSSA served as the central assembly factor, and SOSSB and SOSSC bound overlapping regions on SOSSA, but they did not interact directly with each other. Depletion of SOSSA by small interfering RNA led to dramatic decreases in SOSSB1 and SOSSB2 protein levels, abrogated targeting of SOSSB1 and SOSSB2 to chromatin, increased ionizing radiation sensitivity, caused defective G2/M checkpoint, and impaired homologous recombination repair.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Single Stranded DNA Binding Protein 1 (SSBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Single Stranded DNA Binding Protein 1 (SSBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Single Stranded DNA Binding Protein 1 (SSBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Single Stranded DNA Binding Protein 1 (SSBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Single Stranded DNA Binding Protein 1 (SSBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Single Stranded DNA Binding Protein 1 (SSBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Single Stranded DNA Binding Protein 1 (SSBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Single Stranded DNA Binding Protein 1 (SSBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Single Stranded DNA Binding Protein 1 (SSBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Single Stranded DNA Binding Protein 1 (SSBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Single Stranded DNA Binding Protein 1 (SSBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Single Stranded DNA Binding Protein 1 (SSBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Single Stranded DNA Binding Protein 1 (SSBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Single Stranded DNA Binding Protein 1 (SSBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Single Stranded DNA Binding Protein 1 (SSBP1) ELISA Kit Customized Service Offer
  1. "Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB)."Gene 126:219-225(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
  4. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The layered structure of human mitochondrial DNA nucleoids."J. Biol. Chem. 283:3665-3675(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)."DNA Repair 12:177-187(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4-A resolution."Nat. Struct. Biol. 4:153-157(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human mitochondrial single-stranded DNA-binding protein (HMTSSB)."Submitted (JAN-2007) to the PDB data bank