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Signal Transducing Adaptor Protein 1 (STAP1)

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BRDG1; STAP1; BCR Downstream Signaling 1; Docking protein BRDG1; Stem cell adaptor protein 1

Signal Transducing Adaptor Protein 1 (STAP1)
CCC H124
HGNC 24133
MGI 1926193
PubMed 10518561
RGD 1311584
UniProt Q9ULZ2
Wiki STAP1
STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.
The BRDG1 open reading frame encodes a protein of 295 amino acids. The overall structure of BRDG1 resembles those of docking proteins such as IRS1, IRS2, DOK1, or DOC2. BRDG1 is phosphorylated by TEC directly in vitro. Studies revealed, furthermore, that BRDG1 appears to function as a docking protein acting downstream of TEC in BCR signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Transducing Adaptor Protein 1 (STAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Transducing Adaptor Protein 1 (STAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Transducing Adaptor Protein 1 (STAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Protein 1 (STAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Protein 1 (STAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH124Mu01 Recombinant Signal Transducing Adaptor Protein 1 (STAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH124Mu01 Polyclonal Antibody to Signal Transducing Adaptor Protein 1 (STAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Protein 1 (STAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Protein 1 (STAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH124Ra01 Recombinant Signal Transducing Adaptor Protein 1 (STAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH124Ra01 Polyclonal Antibody to Signal Transducing Adaptor Protein 1 (STAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Protein 1 (STAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Protein 1 (STAP1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase."Proc. Natl. Acad. Sci. U.S.A. 96:11976-11981(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of the PH domain of human docking protein BRDG1."Submitted (OCT-2005) to the PDB data bank