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Serine/Threonine Kinase 4 (STK4)

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MST1; KRS2; YSK3; Mammalian Sterile 20-Like 1; Yeast Ste20-Like; Kinase Responsive To Stress 2; Mammalian STE20-like protein kinase 1; Serine/threonine-protein kinase Krs-2

Serine/Threonine Kinase 4 (STK4)
CCC H118
HGNC 11408
MGI 1929004
PubMed 22294732
RGD 1312035
UniProt Q13043
Wiki STK4
STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
Sequence analysis indicated that the N terminus of the deduced 487-amino acid STK4 protein contains the 11 subdomains typical of an STK. The C terminus of STK4 is highly acidic.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 4 (STK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 4 (STK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 4 (STK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 4 (STK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 4 (STK4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 4 (STK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 4 (STK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 4 (STK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 4 (STK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 4 (STK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 4 (STK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 4 (STK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 4 (STK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 4 (STK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 4 (STK4) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a human protein kinase with homology to Ste20."J. Biol. Chem. 270:21695-21700(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2."Proc. Natl. Acad. Sci. U.S.A. 93:10099-10104(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUL-2007) to UniProtKB
  7. "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain."J. Biol. Chem. 271:21049-21053(1996) [PubMed] [Europe PMC] [Abstract]
  8. "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation."J. Biol. Chem. 276:19276-19285(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation."Proc. Natl. Acad. Sci. U.S.A. 98:10148-10153(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase."Cell 113:507-517(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras."Biochem. J. 381:453-462(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis."Cancer Res. 66:2562-2569(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span."Cell 125:987-1001(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation."FEBS J. 273:4264-4276(2006) [PubMed] [Europe PMC] [Abstract]
  15. "The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1."EMBO J. 26:4523-4534(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation."J. Biol. Chem. 282:30836-30844(2007) [PubMed] [Europe PMC] [Abstract]
  17. "MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation."Curr. Biol. 18:311-321(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling."BioFactors 35:338-345(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1."Biochem. J. 418:93-101(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  23. "RASSF2 associates with and stabilizes the proapoptotic kinase MST2."Oncogene 28:2988-2998(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120."J. Biol. Chem. 285:3815-3824(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner."Cancer Res. 71:946-954(2011) [PubMed] [Europe PMC] [Abstract]
  29. "MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling."Cancer Res. 71:4303-4313(2011) [PubMed] [Europe PMC] [Abstract]
  30. "The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2."J. Biol. Chem. 286:6253-6261(2011) [PubMed] [Europe PMC] [Abstract]
  31. "MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation."J. Biol. Chem. 286:6940-6945(2011) [PubMed] [Europe PMC] [Abstract]
  32. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  33. "The phenotype of human STK4 deficiency."Blood 119:3450-3457(2012) [PubMed] [Europe PMC] [Abstract]
  34. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  35. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  36. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  37. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]