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Sulfotransferase Family 1A, Member 3 (SULT1A3)

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HAST3; M-PST; STM; SULT1A4; TL-PST; Catecholamine-sulfating phenol sulfotransferase; Monoamine-sulfating phenol sulfotransferase; Thermolabile phenol sulfotransferase

Sulfotransferase Family 1A, Member 3 (SULT1A3)
CCC H103
HGNC 11455
PubMed 17908235
UniProt P0DMM9
Wiki SULT1A3
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.
This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Three alternatively spliced variants that encode the same protein have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfotransferase Family 1A, Member 3 (SULT1A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfotransferase Family 1A, Member 3 (SULT1A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfotransferase Family 1A, Member 3 (SULT1A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfotransferase Family 1A, Member 3 (SULT1A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfotransferase Family 1A, Member 3 (SULT1A3) ELISA Kit Customized Service Offer
  1. "Identification of two human brain aryl sulfotransferase cDNAs."Biochem. Biophys. Res. Commun. 195:120-127(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of cDNA encoding human placental estrogen sulfotransferase."Mol. Cell. Endocrinol. 99:R11-R15(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization and DNA sequence of the human catecholamine-sulfating phenol sulfotransferase gene (STM)."Biochem. Biophys. Res. Commun. 205:1325-1332(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization."Biochem. Biophys. Res. Commun. 198:1119-1127(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization."Biochem. Biophys. Res. Commun. 208:786-795(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form."Biochem. Biophys. Res. Commun. 208:855-862(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene."J. Biol. Chem. 269:28200-28205(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2."Genomics 23:275-277(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies."Biochem. J. 302:497-502(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human catecholamine sulfotransferase."J. Mol. Biol. 293:521-530(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate."Biochem. Biophys. Res. Commun. 335:417-423(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism."J. Neurochem. 87:809-819(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies."Biochem. Biophys. Res. Commun. 321:870-878(2004) [PubMed] [Europe PMC] [Abstract]