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Synaptotagmin XIV (SYT14)

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SytXIV; Synaptotagmin XIV

Synaptotagmin XIV (SYT14)
CCC H081
HGNC 23143
MGI 2444490
PubMed 21835308
UniProt Q8NB59
Wiki SYT14
Syt14 formed oligomers independent of Ca(2+). Oligomerization was mainly mediated by fatty-acylated cysteines between the transmembrane domain and spacer domain. The C2 domains of Syt14 bound liposomes made up of phosphatidylcholine and phosphatidylserine.
The deduced 555-amino acid mouse and human SYT14 proteins contain conserved N-terminal extracellular cysteines, followed by a transmembrane domain and C-terminal C-type tandem C2 domains. Database analysis identified a SYT14 homolog in Drosophila, but not in nematode, plant, or yeast. RT-PCR detected highest Syt14 expression in mouse heart and testis, with moderate expression in kidney. In mouse embryos, expression was weak on day 7 and strong on days 11, 15, and 17.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptotagmin XIV (SYT14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptotagmin XIV (SYT14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptotagmin XIV (SYT14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptotagmin XIV (SYT14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptotagmin XIV (SYT14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptotagmin XIV (SYT14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptotagmin XIV (SYT14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptotagmin XIV (SYT14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptotagmin XIV (SYT14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptotagmin XIV (SYT14) ELISA Kit Customized Service Offer
  1. "Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans."J. Biochem. 133:641-649(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Synaptotagmin gene content of the sequenced genomes."BMC Genomics 5:43-43(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation."Am. J. Hum. Genet. 89:320-327(2011) [PubMed] [Europe PMC] [Abstract]