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Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1)

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Ga55; Gastric cancer antigen Ga55; Taxin-1

Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1)
CCC H066
HGNC 11522
MGI 2443510
PubMed 15918899
RGD 1303120
UniProt O75410
Wiki TACC1
Introduction of TACC1 into stable cell lines resulted in morphologic changes consistent with a transformed phenotype and in anchorage-independent growth. However, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.
The predicted 805-amino acid TACC1 protein is rich in serine, proline, and acidic residues, has a 20-amino acid N terminus rich in tryptophan, contains 2 nuclear localization signals but no DNA- or RNA-binding domains, and has a 200-residue C terminus with extensive alpha-helical segments expected to adopt a coiled-coil structure. Northern blot analysis detected a major 8.0-kb TACC1 transcript in all tissues tested, with relatively weak expression in liver and lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1) ELISA Kit Customized Service Offer
  1. "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon."Oncogene 18:4032-4038(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Serological identification and expression analysis of gastric cancer-associated genes."Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Altered splicing pattern of TACC1 mRNA in gastric cancer."Cancer Genet. Cytogenet. 139:78-83(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules."Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."Biochem. J. 363:195-200(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators."Oncogene 21:5619-5630(2002) [PubMed] [Europe PMC] [Abstract]
  11. "TACC1-chTOG-Aurora A protein complex in breast cancer."Oncogene 22:8102-8116(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."Oncogene 23:2559-2563(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Aurora B -TACC1 protein complex in cytokinesis."Oncogene 23:4516-4522(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  16. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein."Biochem. Biophys. Res. Commun. 408:647-653(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]