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Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2)

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AZU-1; ECTACC; Anti-Zuai-1

Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2)
CCC H065
HGNC 11523
MGI 1928899
PubMed 22456197
RGD 1303004
UniProt O95359
Wiki TACC2
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. TACC2 concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.
By searching an EST database with TACC1 as the probe, Still et al. (1999) identified cDNAs encoding TACC2 and TACC3. The coiled-coil region of the 652-amino acid TACC2 protein is highly related to that of TACC1, suggesting that TACC2 arose through gene duplication

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2) ELISA Kit Customized Service Offer
  1. "AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression."Mol. Biol. Cell 11:1357-1367(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules."Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2."Genomics 81:192-201(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells."Cytokine 13:129-137(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "TTK kinase is essential for the centrosomal localization of TACC2."FEBS Lett. 572:51-56(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."Oncogene 23:2559-2563(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]