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Thymine DNA Glycosylase (TDG)

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G/T Mismatch-Specific Thymine DNA Glycosylase; Thymine-DNA glycosylase

Thymine DNA Glycosylase (TDG)
CCC H053
HGNC 11700
MGI 108247
PubMed 21862836
RGD 620959
UniProt Q13569
Wiki TDG
Thymine-DNA Glycosylase(TDG) belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.These cDNAs encode a 410-amino acid, 46-kD polypeptide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH053Hu01 Recombinant Thymine DNA Glycosylase (TDG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH053Hu01 Polyclonal Antibody to Thymine DNA Glycosylase (TDG) WB; IHC; ICC; IP.
MAH053Hu21 Monoclonal Antibody to Thymine DNA Glycosylase (TDG) WB; IHC; ICC; IP.
Assay Kits SEH053Hu ELISA Kit for Thymine DNA Glycosylase (TDG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thymine DNA Glycosylase (TDG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thymine DNA Glycosylase (TDG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thymine DNA Glycosylase (TDG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thymine DNA Glycosylase (TDG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymine DNA Glycosylase (TDG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thymine DNA Glycosylase (TDG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thymine DNA Glycosylase (TDG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thymine DNA Glycosylase (TDG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thymine DNA Glycosylase (TDG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymine DNA Glycosylase (TDG) ELISA Kit Customized Service Offer
  1. "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase."J. Biol. Chem. 271:12767-12774(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells."Proc. Natl. Acad. Sci. U.S.A. 91:1642-1646(1994) [PubMed] [Europe PMC] [Abstract]
  5. "The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells."J. Biol. Chem. 268:21218-21224(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover."EMBO J. 21:1456-1464(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair." Cell 146:67-79(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites."J. Biol. Chem. 286:35334-35338(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1."Nature 435:979-982(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of SUMO-3-modified thymine-DNA glycosylase."J. Mol. Biol. 359:137-147(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition."Proc. Natl. Acad. Sci. U.S.A. 105:8890-8895(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA."Nat. Chem. Biol. 8:328-330(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation."Nucleic Acids Res. 40:10203-10214(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA."Proc. Natl. Acad. Sci. U.S.A. 109:8091-8096(2012) [PubMed] [Europe PMC] [Abstract]