≡

Transcription Factor AP4 (TFAP4)

[Edit]

AP-4; bHLHc41; Activating Enhancer Binding Protein 4; Class C basic helix-loop-helix protein 41

Transcription Factor AP4 (TFAP4)
CCC H044
HGNC 11745
MGI 103239
PubMed 23028375
RGD 1308357
UniProt Q01664
Wiki TFAP4
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG.
The deduced 321-amino acid protein, which lacks the N terminus, contains a basic region, followed by an HLH domain, 2 leucine-rich regions, a Q/P-rich sequence, and a C-terminal acidic domain. Northern blot analysis detected a transcript of about 2 kb in HeLa cells.The leucine-rich repeats, predominantly the second repeat, mediated TFAP4 homodimerization, and the HLH domain mediated heterodimerization of TFAP4 with E12 (TCF3).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP4 (TFAP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP4 (TFAP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP4 (TFAP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP4 (TFAP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP4 (TFAP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP4 (TFAP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP4 (TFAP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP4 (TFAP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP4 (TFAP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP4 (TFAP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP4 (TFAP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP4 (TFAP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP4 (TFAP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP4 (TFAP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP4 (TFAP4) ELISA Kit Customized Service Offer
  1. "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function."J. Virol. 68:7188-7199(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]