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TGFB Induced Factor 1 (TGIF1)

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TGIF; HPE4; 5'-TG-3'-interacting factor 1; Homeobox protein TGIF1

TGFB Induced Factor 1 (TGIF1)
CCC H037
HGNC 11776
MGI 1194497
PubMed 18816846
RGD 1310517
UniProt Q15583
Wiki TGIF1
TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TGFB Induced Factor 1 (TGIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TGFB Induced Factor 1 (TGIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TGFB Induced Factor 1 (TGIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TGFB Induced Factor 1 (TGIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TGFB Induced Factor 1 (TGIF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TGFB Induced Factor 1 (TGIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TGFB Induced Factor 1 (TGIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TGFB Induced Factor 1 (TGIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TGFB Induced Factor 1 (TGIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TGFB Induced Factor 1 (TGIF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TGFB Induced Factor 1 (TGIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TGFB Induced Factor 1 (TGIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TGFB Induced Factor 1 (TGIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TGFB Induced Factor 1 (TGIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TGFB Induced Factor 1 (TGIF1) ELISA Kit Customized Service Offer
  1. "A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif."J. Biol. Chem. 270:31178-31188(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription."J. Biol. Chem. 275:20734-20741(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, northeast structural genomics consortium target hr4411b."Submitted (OCT-2011) to the PDB data bank
  7. "Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination."Nat. Genet. 25:205-208(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: mutation review and genotype-phenotype correlations."Hum. Mutat. 24:43-51(2004) [PubMed] [Europe PMC] [Abstract]