Transglutaminase 5 (TGM5)
[Edit]TGX; TGMX; Transglutaminase X; Protein-glutamine gamma-glutamyltransferase 5
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TGM5 encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.
TGM5 contains the conserved structural requirements for transglutaminase activity and calcium binding. Overall, TGM5 shares 40%, 42%, 35%, and 31% protein sequence identity with TGC (TGM2), TGE (TGM3), TGK (TGM1), and TGP (TGM4), respectively. Northern blot analysis revealed that TGM5 is expressed as 2.2- and 2.8-kb mRNAs in foreskin keratinocytes.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transglutaminase 5 (TGM5) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transglutaminase 5 (TGM5) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transglutaminase 5 (TGM5) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transglutaminase 5 (TGM5) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transglutaminase 5 (TGM5) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transglutaminase 5 (TGM5) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transglutaminase 5 (TGM5) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transglutaminase 5 (TGM5) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transglutaminase 5 (TGM5) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transglutaminase 5 (TGM5) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transglutaminase 5 (TGM5) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transglutaminase 5 (TGM5) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transglutaminase 5 (TGM5) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transglutaminase 5 (TGM5) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transglutaminase 5 (TGM5) | ELISA Kit Customized Service Offer |
- "Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers."J. Biol. Chem. 273:3452-3460(1998) [PubMed] [Europe PMC] [Abstract]
- "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z."J. Biol. Chem. 276:33066-33078(2001) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Transglutaminase 5 is acetylated at the N-terminal end."Amino Acids 26:425-430(2004) [PubMed] [Europe PMC] [Abstract]
- "A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome."Am. J. Hum. Genet. 77:909-917(2005) [PubMed] [Europe PMC] [Abstract]