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Thyroid Hormone Receptor Associated Protein 1 (THRAP1)

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MED13; TRAP240; Mediator Complex Subunit 13; Thyroid hormone receptor-associated protein complex 240 kDa component; Activator-recruited cofactor 250 kDa component

Thyroid Hormone Receptor Associated Protein 1 (THRAP1)
CCC H026
HGNC 22474
MGI 3029632
PubMed 22162340
RGD 1304829
UniProt Q9UHV7
THRAP1 encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.The TRAP240 cDNA encodes a 2,174-amino acid protein that shows a regional identity of 29% and a similarity of 46% with a hypothetical C. elegans protein (CEK08F8 and CEF07H5).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroid Hormone Receptor Associated Protein 1 (THRAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Hormone Receptor Associated Protein 1 (THRAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroid Hormone Receptor Associated Protein 1 (THRAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Hormone Receptor Associated Protein 1 (THRAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Associated Protein 1 (THRAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroid Hormone Receptor Associated Protein 1 (THRAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Hormone Receptor Associated Protein 1 (THRAP1) ELISA Kit Customized Service Offer
  1. "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."Mol. Cell 3:361-370(1999) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  8. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]