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Tousled Like Kinase 1 (TLK1)

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PKU-BETA; Serine/threonine-protein kinase tousled-like 1

Tousled Like Kinase 1 (TLK1)
CCC H017
HGNC 11841
MGI 2441683
PubMed 18940270
RGD 1310370
UniProt Q9UKI8
Wiki TLK1
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
The deduced 787-amino acid protein has a 5-domain structure, with N-terminal nuclear localization signals followed by a nucleotide binding motif, and a single catalytic domain near the C terminus. TLK1 shares 86% sequence identity with TLK2 overall, and 94% identity in the catalytic region. Northern blot analysis detected a 4.2-kb transcript expressed primarily in fetal kidney and liver, and in placenta. Immunofluorescence analysis of transfected COS-1 cells localized TLK1 to the nucleus.The deduced 718-amino acid protein has a calculated molecular mass of 81.9 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tousled Like Kinase 1 (TLK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tousled Like Kinase 1 (TLK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tousled Like Kinase 1 (TLK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tousled Like Kinase 1 (TLK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tousled Like Kinase 1 (TLK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tousled Like Kinase 1 (TLK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tousled Like Kinase 1 (TLK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tousled Like Kinase 1 (TLK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tousled Like Kinase 1 (TLK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tousled Like Kinase 1 (TLK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tousled Like Kinase 1 (TLK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tousled Like Kinase 1 (TLK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tousled Like Kinase 1 (TLK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tousled Like Kinase 1 (TLK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tousled Like Kinase 1 (TLK1) ELISA Kit Customized Service Offer
  1. "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal."Gene 202:193-201(1997) [PubMed] [Europe PMC] [Abstract].
  2. "Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly."Mol. Biol. Cell 10:4033-4041(1999) [PubMed] [Europe PMC] [Abstract].
  3. "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases."Curr. Biol. 11:1068-1073(2001) [PubMed] [Europe PMC] [Abstract]
  4. "A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed."Oncogene 20:726-738(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint."EMBO J. 22:1676-1687(2003) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]