Transmembrane Channel Like Protein 1 (TMC1)

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DFNA36; DFNB11; DFNB7; Transmembrane,Cochlear Expressed 1; Transmembrane cochlear-expressed protein 1

Transmembrane Channel Like Protein 1 (TMC1)
TMC1 is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.
The TMC1 protein is predicted to contain 6 transmembrane domains and to have cytoplasmic orientation of N and C termini. Tmc1 mRNA is expressed in hair cells of the postnatal cochlea and vestibular end organs and is required for normal function of cochlear hair cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Channel Like Protein 1 (TMC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Channel Like Protein 1 (TMC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Channel Like Protein 1 (TMC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Channel Like Protein 1 (TMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Channel Like Protein 1 (TMC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Channel Like Protein 1 (TMC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Channel Like Protein 1 (TMC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Channel Like Protein 1 (TMC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Channel Like Protein 1 (TMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Channel Like Protein 1 (TMC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Channel Like Protein 1 (TMC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Channel Like Protein 1 (TMC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Channel Like Protein 1 (TMC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Channel Like Protein 1 (TMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Channel Like Protein 1 (TMC1) ELISA Kit Customized Service Offer
  1. "Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function." Nat. Genet. 30:277-284(2002) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]