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Tumor Protein p53 Binding Protein 2 (TP53BP2)

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53BP2; ASPP2; BBP; PPP1R13A; p53BP2; apoptosis-stimulating protein of p53; Bcl2-binding protein; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2

Tumor Protein p53 Binding Protein 2 (TP53BP2)
CCC H008
HGNC 12000
MGI 2138319
PubMed 24127607
RGD 1305461
UniProt Q13625
Wiki TP53BP2
TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. Sequence analysis determined that BBP is identical to TP53BP2. Binding analysis showed that the ankyrin repeats and SH3 domain of TP53BP2 are required for interaction with both p53 and BCL2 and that TP53BP2 cannot bind to both proteins simultaneously.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 2 (TP53BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 2 (TP53BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 2 (TP53BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 2 (TP53BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 2 (TP53BP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 2 (TP53BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 2 (TP53BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 2 (TP53BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 2 (TP53BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 2 (TP53BP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 2 (TP53BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 2 (TP53BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 2 (TP53BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 2 (TP53BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 2 (TP53BP2) ELISA Kit Customized Service Offer
  1. "The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M."Mol. Cell. Biol. 16:3884-3892(1996) [PubMed] [Europe PMC] [Abstract]
  2. "ASPP proteins specifically stimulate the apoptotic function of p53."Mol. Cell 8:781-794(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Two cellular proteins that bind to wild-type but not mutant p53."Proc. Natl. Acad. Sci. U.S.A. 91:6098-6102(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  8. "NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2."Oncogene 18:5177-5186(1999) [PubMed] [Europe PMC] [Abstract]
  9. "APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus."Cancer Res. 60:101-105(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53."Mol. Cell. Biol. 20:8018-8025(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines."FEBS Lett. 465:124-128(2000) [PubMed] [Europe PMC] [Abstract]
  12. "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis."J. Neurochem. 85:801-809(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis."Oncogene 28:2065-2073(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Identifying tandem Ankyrin repeats in protein structures."BMC Bioinformatics 15:6599-6599(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2."Science 274:1001-1005(1996) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold."J. Mol. Biol. 371:948-958(2007) [PubMed] [Europe PMC] [Abstract]