Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE)

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PGPEP2; TRH-DE; PAP-II; Pyroglutamyl-Peptidase II; TRH-specific aminopeptidase; Thyroliberinase

Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE)
Thyrotropin-releasing hormone (TRH) acts as a stimulator of hormone secretion from adenohypophyseal cells, and its signals are inactivated by TRH-degrading ectoenzyme.
The deduced 1,024-amino acid type II integral transmembrane protein is 96% identical to the rat protein. It has 12 putative C-terminal N-glycosylation sites, a potential tyrosine sulfation site (residue 380), a consensus sequence for zinc-dependent metallopeptidases, and a short N-terminal intracellular domain with a potential phosphorylation site. Northern blot analysis revealed expression of 7.5-, 7.0-, 6.0-, and 4.5-kb transcripts. Strongest expression was in brain, with weaker expression in heart, lung, liver, and skeletal muscle, and no expression in kidney and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) ELISA Kit Customized Service Offer
  1. "Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment."Eur. J. Biochem. 265:415-422(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]