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Alpha-Tocopherol Transfer Protein (TTPa)

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AVED; TTP1; alphaTTP; Ataxia(Friedreich-Like)With Vitamin E Deficiency

Alpha-Tocopherol Transfer Protein (TTPa)
CCC G992
HGNC 12404
MGI 1354168
PubMed 23186252
RGD 3915
UniProt P49638
TTPa encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
Using rat alpha-Ttp to screen a liver cDNA library, followed by PCR, Arita et al. (1995) cloned full-length human alpha-TTP. The deduced 278-amino acid protein has a calculated molecular mass of 31.7 kD and shares 94% identity with rat alpha-Ttp. Northern blot analysis of several human tissues detected a 4.5-kb alpha-TTP transcript in liver only.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-Tocopherol Transfer Protein (TTPa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-Tocopherol Transfer Protein (TTPa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-Tocopherol Transfer Protein (TTPa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-Tocopherol Transfer Protein (TTPa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Tocopherol Transfer Protein (TTPa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG992Mu01 Recombinant Alpha-Tocopherol Transfer Protein (TTPa) Positive Control; Immunogen; SDS-PAGE; WB.
RPG992Mu02 Recombinant Alpha-Tocopherol Transfer Protein (TTPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG992Mu01 Polyclonal Antibody to Alpha-Tocopherol Transfer Protein (TTPa) WB; IHC; ICC; IP.
PAG992Mu02 Polyclonal Antibody to Alpha-Tocopherol Transfer Protein (TTPa) WB; IHC; ICC; IP.
Assay Kits SEG992Mu ELISA Kit for Alpha-Tocopherol Transfer Protein (TTPa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-Tocopherol Transfer Protein (TTPa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-Tocopherol Transfer Protein (TTPa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-Tocopherol Transfer Protein (TTPa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-Tocopherol Transfer Protein (TTPa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Tocopherol Transfer Protein (TTPa) ELISA Kit Customized Service Offer
  1. "Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization."Biochem. J. 306:437-443(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Human alpha-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency."Ann. Neurol. 39:295-300(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Ataxia with isolated vitamin E deficiency: heterogeneity of mutations and phenotypic variability in a large number of families."Am. J. Hum. Genet. 62:301-310(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein."Nat. Genet. 9:141-145(1995) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein."J. Mol. Biol. 331:725-734(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency."Proc. Natl. Acad. Sci. U.S.A. 100:14713-14718(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer protein."N. Engl. J. Med. 333:1313-1318(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular determinants of heritable vitamin E deficiency."Biochemistry 43:4143-4149(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical follow-up and novel mutations in TTPA gene in Italian families."Neurol. Sci. 25:130-137(2004) [PubMed] [Europe PMC] [Abstract]