TXK Tyrosine Kinase (TXK)
[Edit]BTKL; PSCTK5; PTK4; RLK; TKL; PTK4 Protein Tyrosine Kinase 4; Resting lymphocyte kinase
![TXK Tyrosine Kinase (TXK)](/upload/item/img/TXK-Tyrosine-Kinase-(TXK)-96989.jpg)
The complete nucleotide sequence of the cDNA indicated that it was related most closely to EMT, a tyrosine kinase of T cells, and to the B-cell tyrosine kinase BTK, which is mutated in X-linked agammaglobulinemia in humans and X-linked immunodeficiency disease (XID) in mice. Other members of this gene family include BMX and TEC.
TXK, like BTK, is a member of the TEC subfamily of SRC-type (nonreceptor) tyrosine kinases. Like other members of the TEC subfamily, and unlike other SRC kinases, TXK lacks both the N-terminal myristylation signal and the C-terminal regulatory tyrosine. TXK expression is detected primarily in T cells and some myeloid cell lines, but not in a number of other cell types.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant TXK Tyrosine Kinase (TXK) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to TXK Tyrosine Kinase (TXK) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to TXK Tyrosine Kinase (TXK) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for TXK Tyrosine Kinase (TXK) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for TXK Tyrosine Kinase (TXK) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPG989Mu01 | Recombinant TXK Tyrosine Kinase (TXK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAG989Mu01 | Polyclonal Antibody to TXK Tyrosine Kinase (TXK) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for TXK Tyrosine Kinase (TXK) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for TXK Tyrosine Kinase (TXK) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant TXK Tyrosine Kinase (TXK) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to TXK Tyrosine Kinase (TXK) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to TXK Tyrosine Kinase (TXK) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for TXK Tyrosine Kinase (TXK) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for TXK Tyrosine Kinase (TXK) | ELISA Kit Customized Service Offer |
- "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12."Hum. Mol. Genet. 3:897-901(1994) [PubMed] [Europe PMC] [Abstract]
- "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene."Oncogene 12:937-942(1996) [PubMed] [Europe PMC] [Abstract]
- "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4."Biochem. Biophys. Res. Commun. 252:14-19(1998) [PubMed] [Europe PMC] [Abstract]
- "Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes."J. Exp. Med. 190:1147-1154(1999) [PubMed] [Europe PMC] [Abstract]
- "Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes."Mol. Cell. Biol. 21:6939-6950(2001) [PubMed] [Europe PMC] [Abstract]
- "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site."Biol. Pharm. Bull. 25:718-721(2002) [PubMed] [Europe PMC] [Abstract]
- "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription."J. Immunol. 168:2365-2370(2002) [PubMed] [Europe PMC] [Abstract]
- "Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells."Clin. Exp. Immunol. 147:164-175(2007) [PubMed] [Europe PMC] [Abstract]
- "Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk."Immunol. Rev. 228:93-114(2009) [PubMed] [Europe PMC] [Abstract]
- "Solution structure of the SH2 domain of human tyrosine-protein kinase TXK."Submitted (OCT-2006) to the PDB data bank
- "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]