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Thioredoxin Domain Containing Protein 12 (TXNDC12)

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AGR1; ERP18; ERP19; TLP19; hAG-1; Endoplasmic Reticulum Thioredoxin Superfamily Member 18; Protein Disulfide Isomerase Family A,Member 16; Thioredoxin-like protein p19

Thioredoxin Domain Containing Protein 12 (TXNDC12)
CCC G988
HGNC 24626
MGI 1913323
PubMed 23978379
RGD 1305960
UniProt O95881
Wiki TXNDC12
TXNDC12 belongs to the thioredoxin superfamily. Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors.The deduced 172-amino acid protein has a calculated molecular mass of 19.2 kD. TLP19 has an N-terminal signal peptide and a central thioredoxin-like domain containing the consensus active-site motif. Northern blot analysis detected a 1.6-kb TLP19 transcript in all tissues examined, with highest expression in placenta and liver. Placenta also expressed a 1.2-kb TLP19 transcript. Epitope-tagged TLP19 was expressed in the Golgi apparatus of transiently transfected COS-7 cells, and it was secreted into the culture medium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 12 (TXNDC12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 12 (TXNDC12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 12 (TXNDC12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 12 (TXNDC12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 12 (TXNDC12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 12 (TXNDC12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 12 (TXNDC12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 12 (TXNDC12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 12 (TXNDC12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 12 (TXNDC12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 12 (TXNDC12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 12 (TXNDC12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 12 (TXNDC12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 12 (TXNDC12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 12 (TXNDC12) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein."Gene 315:71-78(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member."J. Biol. Chem. 278:28912-28920(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase."Biochemistry 48:4596-4606(2009) [PubMed] [Europe PMC] [Abstract]