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Ubiquilin 4 (UBQLN4)

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A1U; UBIN; C1orf6; CIP75; A1Up; Connexin43-interacting protein of 75 kDa; Ataxin-1 ubiquitin-like-interacting protein A1U; Ataxin-1 interacting ubiquitin-like protein

Ubiquilin 4 (UBQLN4)
CCC G946
HGNC 1237
MGI 2150152
PubMed 23459205
RGD 1308273
UniProt Q9NRR5
Sequence comparison revealed that A1U contains an N-terminal ubiquitin-like region, placing it within a large family of similar proteins. In addition, A1U shows substantial homology to human UBQLN2, a protein that binds the ATPase domain of the HSP70-like STCH protein. Expression analyses demonstrated that A1U mRNA is widely expressed as a 4.0-kb transcript and is present in Purkinje cells, the primary site of spinocerebellar ataxia-1 (SCA1) cerebellar pathology.
The A1U protein localized to the nucleus and cytoplasm of transfected COS-1 cells. Sequences important for the transport of A1U into the nucleus appeared to lie within the C terminus. In the nucleus, A1U colocalized with mutant ataxin-1 (ATX1), further demonstrating that A1U interacts with ataxin-1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG946Hu01 Recombinant Ubiquilin 4 (UBQLN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquilin 4 (UBQLN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquilin 4 (UBQLN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquilin 4 (UBQLN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquilin 4 (UBQLN4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquilin 4 (UBQLN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquilin 4 (UBQLN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquilin 4 (UBQLN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquilin 4 (UBQLN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquilin 4 (UBQLN4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquilin 4 (UBQLN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquilin 4 (UBQLN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquilin 4 (UBQLN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquilin 4 (UBQLN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquilin 4 (UBQLN4) ELISA Kit Customized Service Offer
  1. "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein."Hum. Mol. Genet. 9:2305-2312(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of two paralogous regions mapping to the short and long arms of human chromosome 2 comprising LIS1 pseudogenes."Cytogenet. Cell Genet. 86:225-232(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up."J. Biol. Chem. 279:42290-42301(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]