≡

UDP Glucose Pyrophosphorylase 2 (UGP2)

[Edit]

UDPGP; UTP--glucose-1-phosphate uridylyltransferase

UDP Glucose Pyrophosphorylase 2 (UGP2)
CCC G939
HGNC 12527
MGI 2183447
PubMed 9119383
RGD 1310210
UniProt Q16851
UDP Glucose Pyrophosphorylase 2 is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme.
The UDPG gene encodes a predicted 508-amino acid protein with no homology to the bacterial protein, but with 47% identity with potato UDPG. On Northern blots, the 2.2-kb UDPG mRNA is expressed in all tissues tested, with the highest levels in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucose Pyrophosphorylase 2 (UGP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucose Pyrophosphorylase 2 (UGP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucose Pyrophosphorylase 2 (UGP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UDP Glucose Pyrophosphorylase 2 (UGP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for UDP Glucose Pyrophosphorylase 2 (UGP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucose Pyrophosphorylase 2 (UGP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucose Pyrophosphorylase 2 (UGP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucose Pyrophosphorylase 2 (UGP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UDP Glucose Pyrophosphorylase 2 (UGP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for UDP Glucose Pyrophosphorylase 2 (UGP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucose Pyrophosphorylase 2 (UGP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucose Pyrophosphorylase 2 (UGP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucose Pyrophosphorylase 2 (UGP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UDP Glucose Pyrophosphorylase 2 (UGP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for UDP Glucose Pyrophosphorylase 2 (UGP2) ELISA Kit Customized Service Offer
  1. "Cloning of a human liver UDP-glucose pyrophosphorylase cDNA by complementation of the bacterial galU mutation."FEBS Lett. 329:153-158(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli."Eur. J. Biochem. 235:173-179(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The importance of conserved residues in human liver UDPglucose pyrophosphorylase."Eur. J. Biochem. 236:723-728(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity."Biochem. J. 442:283-291(2012) [PubMed] [Europe PMC] [Abstract]