WNK Lysine Deficient Protein Kinase 1 (WNK1)
[Edit]HSN2; KDP; PHA2C; PRKWNK1; HSAN2; Protein Kinase,Lysine Deficient 1; Hereditary Sensory Neuropathy, Type II; Erythrocyte 65 kDa protein; Kinase deficient protein
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The WNK1 protein is composed of 2382 amino acids. The protein contains a small N-terminal domain followed by the kinase domain and a long C-terminal tail. The kinase domain has some similarity to the MEKK protein kinase family.
The protein appears to be part of the ERK5 MAP kinase pathway upstream of MEKK2 / MEKK3 and to function as a tetramer. It selectively binds to and phosphorylates synaptotagmin 2 (SYT2) within its calcium binding C2 domains. It activates the serum- and glucocorticoid-inducible protein kinase SGK1, leading to activation of the epithelial sodium channel. It along with WNK4 stimulates clathrin-dependent endocytosis of renal outer medullar potassium 1 (ROMK1). It (and WNK4) interactes with intersectin (ITSN1, ITSN2).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG892Hu01 | Recombinant WNK Lysine Deficient Protein Kinase 1 (WNK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAG892Hu01 | Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 1 (WNK1) | WB; IHC |
| Assay Kits | n/a | CLIA Kit for WNK Lysine Deficient Protein Kinase 1 (WNK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for WNK Lysine Deficient Protein Kinase 1 (WNK1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant WNK Lysine Deficient Protein Kinase 1 (WNK1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 1 (WNK1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 1 (WNK1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for WNK Lysine Deficient Protein Kinase 1 (WNK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for WNK Lysine Deficient Protein Kinase 1 (WNK1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant WNK Lysine Deficient Protein Kinase 1 (WNK1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 1 (WNK1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 1 (WNK1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for WNK Lysine Deficient Protein Kinase 1 (WNK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for WNK Lysine Deficient Protein Kinase 1 (WNK1) | ELISA Kit Customized Service Offer |
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