Zonadhesin (ZAN)
Zonadhesin (ZAN) is a sperm membrane protein that binds the zona pellucida of the egg in a species-specific manner. Once bound, the acrosomal reaction is triggered, involving exocytosis of the acrosome, creating an acrosomal shroud. Next, the sperm penetrates the egg zona pellucida, enters the perivitelline space between the zona pellucida and the plasma membrane, and then fuses with the plasma membrane. The zonadhesin protein, encoded by the ZAN gene, localizes to the anterior part of the sperm head and acts as a receptor to the zona pellucida matrix of the egg. Like other male reproductive proteins located in the acrosome or sperm head and proposed to be involved in species-specific binding to eggs, ZAN possesses high levels of divergence between closely related species.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zonadhesin (ZAN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zonadhesin (ZAN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zonadhesin (ZAN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zonadhesin (ZAN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zonadhesin (ZAN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zonadhesin (ZAN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zonadhesin (ZAN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zonadhesin (ZAN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zonadhesin (ZAN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zonadhesin (ZAN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zonadhesin (ZAN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zonadhesin (ZAN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zonadhesin (ZAN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zonadhesin (ZAN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zonadhesin (ZAN) ELISA Kit Customized Service Offer
  1. "Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution."Am. J. Hum. Genet. 79:820-830(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN)."Genomics 41:119-122(1997) [PubMed] [Europe PMC] [Abstract]
  6. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]