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Zinc And Ring Finger Protein 2 (ZNRF2)

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RNF202; Protein Ells2; E3 ubiquitin-protein ligase ZNRF2

Zinc And Ring Finger Protein 2 (ZNRF2)
CCC G866
HGNC 22316
MGI 1196246
PubMed 19648646
RGD 1306645
UniProt Q8NHG8
ZNRF2 was also widely expressed in nonneural tissues, including mammary gland, testis, colon, and kidney. In situ hybridization of mouse pups and immunohistochemical analysis of adult mouse tissues revealed Znrf2 expression throughout the central nervous system and in sensory neurons of the peripheral nervous system.
Znrf2 was expressed in mature sperm, but not developing spermatogonia, as well as in adipose tissue, columnar epithelia of the gut, and hair follicles. Immunohistochemical analysis and fractionation of adult mouse brain localized Znrf1 and Znrf2 to the presynaptic region, with Znrf1 on synaptic vesicles and Znrf2 on presynaptic plasma membranes. In mouse fibroblasts, fluorescence-tagged Znrf2 colocalized with an endosome/lysosome marker.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc And Ring Finger Protein 2 (ZNRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc And Ring Finger Protein 2 (ZNRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc And Ring Finger Protein 2 (ZNRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc And Ring Finger Protein 2 (ZNRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc And Ring Finger Protein 2 (ZNRF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc And Ring Finger Protein 2 (ZNRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc And Ring Finger Protein 2 (ZNRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc And Ring Finger Protein 2 (ZNRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc And Ring Finger Protein 2 (ZNRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc And Ring Finger Protein 2 (ZNRF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc And Ring Finger Protein 2 (ZNRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc And Ring Finger Protein 2 (ZNRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc And Ring Finger Protein 2 (ZNRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc And Ring Finger Protein 2 (ZNRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc And Ring Finger Protein 2 (ZNRF2) ELISA Kit Customized Service Offer
  1. "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases."J. Neurosci. 23:9385-9394(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation."J. Cell. Biochem. 97:572-582(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]