≡

Tubulin Gamma Complex Associated protein 4 (TUBgCP4)

[Edit]

GCP4; Gamma-Tubulin Complex Component 4; Gamma-ring complex protein 76 kDa

Tubulin Gamma Complex Associated protein 4 (TUBgCP4)
CCC G860
HGNC 16691
MGI 1196293
PubMed 23666744
UniProt Q9UGJ1
Wiki TUBGCP4
GCP4 deduced 667-amino acid protein has a calculated molecular mass of 76 kD and shows sequence identity with the C-terminal regions of human centrosomal proteins 103p (TUBGCP2) and 104p (TUBGCP3).
By coimmunoprecipitation, Fava et al. (1999) demonstrated that GCP4 associated in complex with gamma-tubulin (TUBG1) in mammalian cells and Xenopus oocytes. Immunofluorescence showed that GCP4 colocalized with gamma-tubulin at centrosomes in mammalian cells. During mitosis, Gcp4 localized to the metaphase spindle and showed transiently increased expression on centrosomes. Gcp4 was present in Xenopus sperm basal bodies, and antibody depletion experiments showed that it was necessary for aster nucleation by sperm basal bodies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Gamma Complex Associated protein 4 (TUBgCP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Gamma Complex Associated protein 4 (TUBgCP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Gamma Complex Associated protein 4 (TUBgCP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Gamma Complex Associated protein 4 (TUBgCP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Gamma Complex Associated protein 4 (TUBgCP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Gamma Complex Associated protein 4 (TUBgCP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Gamma Complex Associated protein 4 (TUBgCP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Gamma Complex Associated protein 4 (TUBgCP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Gamma Complex Associated protein 4 (TUBgCP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Gamma Complex Associated protein 4 (TUBgCP4) ELISA Kit Customized Service Offer
  1. "Human 76p: a new protein member of the gamma-tubulin associated protein family."J. Cell Biol. 147:857-868(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation."Dev. Cell 5:113-125(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]