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Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb)

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PIK4CB; PI4K-BETA; pi4K92

Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb)
CCC G844
HGNC 8984
MGI 1334433
PubMed 22124328
RGD 621214
UniProt Q9UBF8
Wiki PI4KB
The predicted 801-amino acid PI4K-beta protein contains an N-terminal lipid kinase unique domain, which is shared by members of both the PI 3-kinase and PI 4-kinase families, and a C-terminal catalytic domain, which defines this protein as a member of a much larger protein/lipid kinase family.
PI4K-beta shares significant amino acid sequence similarity with yeast PIK1. Western blot analysis of mammalian cell lysates using an antibody against PI4K-beta detected a 110-kD protein. Northern blot analysis showed that PI4K-beta is ubiquitously expressed as an approximately 4-kb transcript, with highest expression in heart, pancreas, and skeletal muscle.Using the green fluorescent protein system, they demonstrated that PIK4CB is localized in the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Kinase Catalytic Beta (PI4Kb) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a novel human phosphatidylinositol 4-kinase."DNA Res. 4:273-280(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene."DNA Res. 4:301-305(1997) [PubMed] [Europe PMC] [Abstract].
  3. "Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase."J. Biol. Chem. 272:4384-4390(1997) [PubMed] [Europe PMC] [Abstract] and Testis.
  4. "Subcellular locations of phosphatidylinositol 4-kinase isoforms."J. Biol. Chem. 272:13236-13241(1997) [PubMed] [Europe PMC] [Abstract]
  5. "ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex."Nat. Cell Biol. 1:280-287(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites."Eur. J. Biochem. 268:2099-2106(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian phosphatidylinositol 4-kinases."IUBMB Life 55:59-65(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta."Traffic 8:1080-1092(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]