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Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a)

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PIK42A; PI4KII; Phosphatidylinositol 4-kinase type II-alpha

Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a)
CCC G841
HGNC 30031
MGI 1934031
PubMed 11244087
RGD 620485
UniProt Q9BTU6
Wiki PI4K2A
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs . By peptide sequencing, database analysis, and RT-PCR of A431 total RNA, they obtained a full-length PI4KII cDNA. The deduced 479-amino acid protein has a calculated molecular mass of about 54 kD. PI4KII has a kinase domain and a leucine zipper, but no transmembrane sequence or acylation motif. Northern blot analysis detected a 6.6-kb transcript in all tissues examined. Expression was highest in kidney, brain, heart, skeletal muscle, and placenta, and was lowest in colon, thymus, and small intestine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Kinase Type 2 Alpha (PI4K2a) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor."J. Cell Sci. 119:571-581(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network."J. Lipid Res. 51:2314-2324(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch."EMBO Rep. 13:1087-1094(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphatidylinositol 4-kinase IIalpha is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner."J. Biol. Chem. 287:21856-21865(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The crystal structure of the phosphatidylinositol 4-kinase IIalpha."EMBO Rep. 15:1085-1092(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIalpha."Nat. Commun. 5:3552-3552(2014) [PubMed] [Europe PMC] [Abstract]