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Inositol Monophosphatase 1 (IMPA1)

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IMP 1; D-galactose 1-phosphate phosphatase; Lithium-sensitive myo-inositol monophosphatase A1

Inositol Monophosphatase 1 (IMPA1)
CCC G835
HGNC 6050
MGI 1933158
PubMed 17068342
RGD 69254
UniProt P29218
Wiki IMPA1
IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol.
This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 1 (IMPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 1 (IMPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 1 (IMPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 1 (IMPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 1 (IMPA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 1 (IMPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 1 (IMPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 1 (IMPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 1 (IMPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 1 (IMPA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 1 (IMPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 1 (IMPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 1 (IMPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 1 (IMPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 1 (IMPA1) ELISA Kit Customized Service Offer
  1. "cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme."Biochem. J. 284:749-754(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA)."Genomics 45:113-122(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Brain inositol monophosphatase identified as a galactose 1-phosphatase."Brain Res. 778:99-106(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of inositol monophosphatase, the putative target of lithium therapy."Proc. Natl. Acad. Sci. U.S.A. 89:10031-10035(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Structural analysis of inositol monophosphatase complexes with substrates."Biochemistry 33:9460-9467(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis."Biochemistry 33:9468-9476(1994) [PubMed] [Europe PMC] [Abstract]
  14. "The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase."Biochemistry 35:10957-10966(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of an enzyme-substrate complex and the catalytic mechanism of human brain myo-inositol monophosphatase."Protein Eng. 10:61-70(1997)
  16. "Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens."Acta Crystallogr. F 68:1149-1152(2012) [PubMed] [Europe PMC] [Abstract]